HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 581949Generated: October 26, 2026
Sodium Hydroxide → 4-Bromo-2-nitroaniline
https://huagongshe.com/reaction/581949
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | N-(4-bromo-2-nitrophenyl)acetamide | HCID 136690 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 4-Bromo-2-nitroaniline | HCID 70132 | — |
Reaction Steps
A mixture of 1d (3.5 g, 13.5 mmol), dimethoxyethane (100 ml) and aqueous sodium hydroxide (50 ml, 1 M) is heated to 80° C. for 1 hour. After cooling the mixture is poured into ice-water. The product is filtered off, washed with water and dried. Yield 2.77 g (94%). Mp 109-1 10° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05922724 |
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| Source dataset | uspto-grants-1999_07 |
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| ORD ID | ord-ce5c175808de4d54af57312909f4641a |
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| Source note | uspto-grants-1999_07 |
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