Potassium Carbonate → (S)-4-(tert-butoxycarbonylamino)-6-chlorothiochromane-7-carboxylic acid
Reaction equation
C[O:2][C:3]([C:5]1[CH:14]=[C:13]2[C:8]([C@@H:9]([NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH2:10][CH2:11][S:12]2)=[CH:7][C:6]=1[Cl:23])=[O:4].C(=O)([O-])[O-].[K+].[K+]>>[C:19]([O:18][C:16]([NH:15][C@@H:9]1[C:8]2[C:13](=[CH:14][C:5]([C:3]([OH:4])=[O:2])=[C:6]([Cl:23])[CH:7]=2)[S:12][CH2:11][CH2:10]1)=[O:17])([CH3:22])([CH3:20])[CH3:21]Participants
3
Procedure
By a similar reaction operation as in Starting Material Synthetic Example 6 using (S)-4-(tert-butoxycarbonylamino)-6-chlorothiochromane-7-carboxylic acid methyl ester (1.10 g) and potassium carbonate (847 mg), the objective (S)-4-(tert-butoxycarbonylamino)-6-chlorothiochromane-7-carboxylic acid (921 mg) was obtained as colorless crystals.
Sources & evidence
- ORD record