Hydrochloric Acid → 5-(3-Bromophenyl)-1H-1,2,4-triazole

HRID 586314

Reaction equation

HRID 586314 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[N:12](COCC[Si](C)(C)C)[N:11]=[CH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.Cl>C(O)C>[Br:1][C:2]1[CH:3]=[C:4]([C:8]2[NH:12][N:11]=[CH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22329519HCID 22329519, compound

Product 1

HCID 124615465-(3-Bromophenyl)-1H-1,2,4-triazoleYield 89.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This reaction was carried out as described in Example 40, step b, using 5-(3-bromophenyl)-1-(2-trimethylsilanylethoxymethyl)-1H-[1,2,4]triazole (2.88 g, 8.1 mmol), 2 N HCl (50 ml) and ethanol (50 ml) to yield the title compound (1.62 g, 89%): 1H NMR (360 MHz, DMSO-d6) δ 8.70 (1H, s), 8.16 (1H, s), 8.01 (1H, d, J 7.8 Hz), 7.63 (1H, d, J 7.8 Hz), 7.46 (1H, t, J 7.8 Hz).

Sources & evidence

ORD record
ord-ed683daacb8b4ec984001d9b2ef31b96
Source dataset
uspto-grants-2005_08
Patent number
US06936608B2

Linked notes

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