1-Fluoro-3-nitrobenzene → 1-Methyl-4-(3-nitrophenyl)piperazine

HRID 586399

Reaction equation

HRID 586399 reaction equation
F[C:2]1[CH:3]=[C:4]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[CH3:11][N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>>[N+:8]([C:4]1[CH:3]=[C:2]([N:15]2[CH2:16][CH2:17][N:12]([CH3:11])[CH2:13][CH2:14]2)[CH:7]=[CH:6][CH:5]=1)([O-:10])=[O:9]

Participants

3

Reactant 2

HCID 98231-Fluoro-3-nitrobenzeneHCID 531671-Methylpiperazine

Product 1

HCID 121521611-Methyl-4-(3-nitrophenyl)piperazine

Conditions

Temperature
120 °C

Procedure

A mixture of 3-fluoronitrobenzene (20 ml; 0.19 mol) and 1-methylpiperazine (40 ml; 0.36 mol) was heated to 120° C. for a week. The cooled mixture was purified by column-chromatography on silica gel using a mixture of ethyl acetate and methanol (9:1 v/1) as the eluent. Yield: 33 g (79%).

Workup

  1. customThe cooled mixture was purified by column-chromatography on silica gel using
  2. additiona mixture of ethyl acetate and methanol (9:1 v/1) as the eluent

Sources & evidence

ORD record
ord-ee474b006a704546bf9351a9bd8a51d2
Source dataset
uspto-grants-2005_08
Patent number
US06936613B2

Linked notes

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