Hydrochloric Acid → HCID 178478314, compound

HRID 587485

Reaction equation

HRID 587485 reaction equation
CS[C:3]1[NH:11][C:6]2=[N:7][CH:8]=[CH:9][CH:10]=[C:5]2[N:4]=1.[ClH:12]>>[Cl:12][C:3]1[NH:11][C:6]2=[N:7][CH:8]=[CH:9][CH:10]=[C:5]2[N:4]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178503348HCID 178503348, compound

Product 1

HCID 178478314HCID 178478314, compound

Conditions

Temperature
0 °C

Procedure

2-(Methylthio)-3H-imidazo[4,5-b]pyridine (3.5 g) was dissolved in conc. HCl (10 mL), and then the mixture was cooled to 0° C. Chlorine gas was bubbled through the mixture for 2 h in iced bath. The mixture was poured onto ice, and neutralized to pH 7 with aqueous ammonium solution. The precipitate was collected by filtration to give the title compound as white crystals (1.0 g).

Workup

  1. customChlorine gas was bubbled through the mixture for 2 h in iced bath
  2. additionThe mixture was poured onto ice
  3. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-87cff40eb96648eea3ec8012b120015b
Source dataset
uspto-grants-2016_01
Patent number
US09226921B2

Linked notes

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