HCID 131734416, compound → HCID 131734417, compound
Reaction equation
[C:1]12([O:21][CH2:20][CH2:19][O:18]1)[C:10]1[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=1)[CH2:4][C@@H:3]([CH:11]=[CH:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:2]2>C(OCC)(=O)C.[Pd]>[C:1]12([O:18][CH2:19][CH2:20][O:21]1)[C:10]1[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=1)[CH2:4][C@@H:3]([CH2:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[CH2:2]2Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
To a stirred solution of Pd/C (0.535 g, 0.251 mmol) in ethyl acetate (25 mL), (R)-ethyl 3-(3′,4′-dihydro-2′H-spiro[[1,3]dioxolane-2,1′-naphthalen]-3′-yl)acrylate (2.5 g, 8.67 mmol) was added under nitrogen. Reaction mixture was stirred for 2 h under hydrogen balloon. After completion of reaction, reaction mixture was filtered through celite, concentrated to get the crude compound. This crude compound was used directly in next reaction (2.3 g, 91%); m/z 290.7