Hydrazine hydrate (1:1) → 2-Oxoindoline-5-carbohydrazide

Participants

Reaction Conditions

Reaction Steps

To a solution of methyl 2-oxoindoline-5-carboxylate (0.40 g, 4.8 mmol) in EtOH (8 ml) was added hydrazine monohydrate (2 ml), and the mixture was stirred for 6 h at 80° C. The mixture was cooled to room temperature, and the resulting precipitate was filtered and dried to afford 2-oxoindoline-5-carbohydrazide (0.25 g, 63%).

Provenance & Evidence