Hydrazine hydrate (1:1) → HCID 90418397, compound

HRID 588266Notes

Reaction equation

HRID 588266 reaction equation
[O:1]=[C:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:11]([O:13]C)=O)[CH:8]=2)[NH:3]1.O.[NH2:16][NH2:17]>CCO>[O:1]=[C:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:11]([NH:16][NH2:17])=[O:13])[CH:8]=2)[NH:3]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 2773516Methyl 2,3-dihydro-2-oxo-1H-indole-5-carboxylate

Product 1

HCID 90418397HCID 90418397, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of methyl 2-oxoindoline-5-carboxylate (0.40 g, 4.8 mmol) in EtOH (8 ml) was added hydrazine monohydrate (2 ml), and the mixture was stirred for 6 h at 80° C. The mixture was cooled to room temperature, and the resulting precipitate was filtered and dried to afford 2-oxoindoline-5-carbohydrazide (0.25 g, 63%).

Workup

  1. temperatureThe mixture was cooled to room temperature
  2. filtrationthe resulting precipitate was filtered
  3. customdried

Sources & evidence

ORD record
ord-e5342dc332474d8a8f7145d33e1718e3
Source dataset
uspto-grants-2016_01
Patent number
US09227962B2

Reaction notes

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