Hydrochloric Acid → HCID 178462754, compound
Reaction equation
CO[CH:3](OC)[CH2:4][NH:5][C:6](=[O:12])[C:7]([NH:9][CH2:10][CH3:11])=[O:8].Cl>C(O)(=O)C>[CH2:4]([N:5]1[CH:11]=[CH:10][N:9]=[C:7]([OH:8])[C:6]1=[O:12])[CH3:3]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
67.5 g (330 mM) of N-(2,2-dimethoxyethyl)-N′-ethylethanediamide and 2 ml of concentrated hydrochloric acid, in 390 ml of acetic acid, were refluxed under stirring for 1 h. The solvent was removed under vacuum to give an oil, which was further purified by silica gel column chromatography, using dichloromethane/methanol (95/5) as eluant to give 37 g of 1-ethyl-3-hydroxy pyrazine-2(1H)-one as an oil.
Workup
- customThe solvent was removed under vacuum
- customto give an oil, which
- customwas further purified by silica gel column chromatography
Sources & evidence
- ORD record
- ord-c0a95c11ef154d618eda6cbb6341e7c7
- Source dataset
- uspto-grants-2016_01
- Patent number
- US09233937B2
Reaction notes
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