3-Iodobenzonitrile → HCID 66747575, compound

HRID 591189

Reaction equation

I[C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]#[N:6].C([Mg]Cl)(C)C.[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2(/[CH:26]=[CH:27]/[N+:28]([O-:30])=[O:29])[CH2:25][CH2:24][CH2:23]2)=[CH:18][CH:17]=1>O1CCCC1>[Cl:15][C:16]1[CH:17]=[CH:18][C:19]([C:22]2([CH:26]([C:2]3[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=3)[C:5]#[N:6])[CH2:27][N+:28]([O-:30])=[O:29])[CH2:23][CH2:24][CH2:25]2)=[CH:20][CH:21]=1

Participants

Conditions

Temperature: -30 °C

Procedure

3-Iodobenzonitrile (3.76 g, 16.41 mmol) dissolved in tetrahydrofuran (1.5 ml) was cooled to −30° C. A solution of isopropylmagnesium chloride in tetrahydrofuran (2 M, 8.84 ml, 17.67 mmol) was added dropwise at −30° C. over 25 min. The reaction mixture was cooled to −78° C. A solution of (E)-1-chloro-4(1-(2-nitrovinyl)cyclobutyl)benzene (3.0 g, 12.62 mmol) in tetrahydrofuran (0.5 ml) was added dropwise. Aqueous work-up yielded the desired product which was used without further purification for the next step. Yield: 3.3 g (8.71 mmol, 69%, purity: 90% by HPLC)

Workup

temperatureThe reaction mixture was cooled to −78° C

Sources & evidence

ORD record: ord-cde9f28cd1db4726858e34a5e8ffca89
Source dataset: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09238619B2

Linked notes

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