Sodium Hydroxide → (7-Chloro-6-hydroxy-1-benzofuran-3-yl)acetic acid

HRID 591464

Reaction equation

HRID 591464 reaction equation
[OH-:1].[Na+].[Cl:3][C:4]1[C:5]([OH:17])=[CH:6][CH:7]=[C:8]2[C:13]=1[O:12][C:11](=[O:14])[CH:10]=[C:9]2[CH2:15]Cl>Cl>[Cl:3][C:4]1[C:13]2[O:12][CH:15]=[C:9]([CH2:10][C:11]([OH:14])=[O:1])[C:8]=2[CH:7]=[CH:6][C:5]=1[OH:17]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 897679298-Chloro-4-(chloromethyl)-7-hydroxy-2H-chromen-2-one

Product 1

HCID 89767735(7-Chloro-6-hydroxy-1-benzofuran-3-yl)acetic acid

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 1N NaOH (56.7 mL) and 8-chloro-4-(chloromethyl)-7-hydroxy-2H-chromen-2-one (2.78 g) was stirred at 100° C. for 1 h. After cooling, the reaction mixture was acidified with 6N HCl (10 mL). The precipitate was collected by filtration to give the title compound (1.65 g).

Workup

  1. temperatureAfter cooling
  2. filtrationThe precipitate was collected by filtration

Sources & evidence

ORD record
ord-9cb8e4a309144364acb0d39132346473
Source dataset
uspto-grants-2016_01
Patent number
US09238639B2

Linked notes

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