L-Lysine → zinc L-lysinate

HRID 593231

Reaction equation

HRID 593231 reaction equation
[OH-].[Zn+2:2].[OH-].[NH2:4][C@H:5]([C:11]([OH:13])=[O:12])[CH2:6][CH2:7][CH2:8][CH2:9][NH2:10]>C(O)C>[NH2:4][C@H:5]([C:11]([O-:13])=[O:12])[CH2:6][CH2:7][CH2:8][CH2:9][NH2:10].[NH2:4][C@H:5]([C:11]([O-:13])=[O:12])[CH2:6][CH2:7][CH2:8][CH2:9][NH2:10].[Zn+2:2]

Participants

4

Reactant 2

HCID 5962L-LysineHCID 9812759Zinc Hydroxide

Product 1

HCID 14772515zinc L-lysinateYield 92.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A stirred mixture of zinc hydroxide (4.48 g, 45 mmol) and L-lysine (13.45 g, 92 mmol) in ethanol (300 mL) was refluxed for 4 h (became very thick and required mechanical stirring). The above mixture was cooled to room temperature and filtered (slowly), collected, and dried in vacuo. The wet solid was triturated from acetonitrile and dried to afford 14.80 g (92%) of zinc bis-lysinate as a white powder.

Workup

  1. temperaturewas refluxed for 4 h (
  2. filtrationfiltered (slowly),
  3. customcollected
  4. customdried in vacuo
  5. customThe wet solid was triturated from acetonitrile
  6. customdried

Sources & evidence

ORD record
ord-fcdf202eb4fc4de29b15fc23901d7c29
Source dataset
uspto-grants-2016_01
Patent number
US09242008B2

Linked notes

Loading…