L-Lysine → zinc L-lysinate
Reaction equation
[OH-].[Zn+2:2].[OH-].[NH2:4][C@H:5]([C:11]([OH:13])=[O:12])[CH2:6][CH2:7][CH2:8][CH2:9][NH2:10]>C(O)C>[NH2:4][C@H:5]([C:11]([O-:13])=[O:12])[CH2:6][CH2:7][CH2:8][CH2:9][NH2:10].[NH2:4][C@H:5]([C:11]([O-:13])=[O:12])[CH2:6][CH2:7][CH2:8][CH2:9][NH2:10].[Zn+2:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A stirred mixture of zinc hydroxide (4.48 g, 45 mmol) and L-lysine (13.45 g, 92 mmol) in ethanol (300 mL) was refluxed for 4 h (became very thick and required mechanical stirring). The above mixture was cooled to room temperature and filtered (slowly), collected, and dried in vacuo. The wet solid was triturated from acetonitrile and dried to afford 14.80 g (92%) of zinc bis-lysinate as a white powder.
Workup
- temperaturewas refluxed for 4 h (
- filtrationfiltered (slowly),
- customcollected
- customdried in vacuo
- customThe wet solid was triturated from acetonitrile
- customdried
Sources & evidence
- ORD record
- ord-fcdf202eb4fc4de29b15fc23901d7c29
- Source dataset
- uspto-grants-2016_01
- Patent number
- US09242008B2
Reaction notes
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