Hydroxylamine → 2-Methyl-1-(propylamino)propan-2-ol

Reaction equation

C(OC(N[C:9]1[CH2:10][C:11](C(O)=O)=[CH:12][C:13]2[CH:19]=CC(C3C=CC(C(N4CCCC4)=O)=CC=3)=C[C:14]=2[N:15]=1)=O)(C)(C)C.N[OH:37]>>[CH3:12][C:13]([OH:37])([CH3:19])[CH2:14][NH:15][CH2:9][CH2:10][CH3:11]

Participants

Reactant 2

HCID 787Hydroxylamine

HCID 66960164(1E,4E)-2-(tert-butoxycarbonylamino)-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxylic acid

Product 1

HCID 392350302-Methyl-1-(propylamino)propan-2-ol

Procedure

The following examples 115 and 117 were prepared by the procedures as described in Example 101 (Steps H and I) using (1E,4E)-2-(tert-butoxycarbonylamino)-8-(4-(pyrrolidine-1-carbonyl)phenyl)-3H-benzo[b]azepine-4-carboxylic acid and the appropriate amines (2-methyl-1-(propylamino)propan-2-ol was prepared by the procedure reported in J. Am. Chem. Soc. 1939, 61, 3562) or the hydroxylamine.

Workup

customThe following examples 115 and 117 were prepared by the procedures

Sources & evidence

ORD record: ord-7f643849ad35424a83ec3931029fae9e
Source dataset: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09242964B2

Reaction notes

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