Propylamine → 2-methyl-N-propylalaninamide

HRID 596813Notes

Reaction equation

HRID 596813 reaction equation
[NH2:1][C:2]([CH3:8])([CH3:7])[C:3](OC)=[O:4].[CH2:9]([NH2:12])[CH2:10][CH3:11]>CO>[CH2:9]([NH:12][C:3](=[O:4])[C:2]([NH2:1])([CH3:8])[CH3:7])[CH2:10][CH3:11]

Participants

4

Reactant 2

HCID 7852PropylamineHCID 4186341Methyl 2-amino-2-methylpropanoate

Product 1

HCID 214480362-methyl-N-propylalaninamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 26.3 parts of methyl 2-amino-2-methylpropionate in methanol is added 70 parts of n-propylamine. The mixture is placed in a bomb and left at a temperature of 100° C. for one week. The solvents are then stripped off under reduced pressure. Distillation of the residual oil affords N1 -propyl-2-amino-2-methylpropionamide, boiling at 58° C. at 0.1 mm pressure.

Workup

  1. waitleft at a temperature of 100° C. for one week
  2. distillationDistillation of the residual oil

Sources & evidence

ORD record
ord-065463928e104051adfab8401ac48500
Source dataset
uspto-grants-1977_03
Patent number
US04012367

Reaction notes

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