Hydrazine hydrate (1:1) → 7-Chloro-2-hydrazinyl-5-phenyl-3H-1,4-benzodiazepine

HRID 597075

Reaction equation

HRID 597075 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=S)[CH2:9][N:8]=[C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:6]=2[CH:19]=1.O.[NH2:21][NH2:22]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([NH:21][NH2:22])[CH2:9][N:8]=[C:7]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:6]=2[CH:19]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 826706Thionordiazepam

Product 1

HCID 123908747-Chloro-2-hydrazinyl-5-phenyl-3H-1,4-benzodiazepine

Procedure

A mixture of 7-chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-thione and hydrazine hydrate is allowed to stand for 72 hours at about 25° C. After evaporation of the ethanol, the solid products obtained are recrystallized from methylene chloride-benzene to give 7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine of melting point 204°-207° C.

Workup

  1. customAfter evaporation of the ethanol
  2. customthe solid products obtained
  3. customare recrystallized from methylene chloride-benzene

Sources & evidence

ORD record
ord-5427413b7754496a8b7156cf9e16122d
Source dataset
uspto-grants-1977_03
Patent number
US04012413

Linked notes

Loading…