Hydrochloric Acid → Chloromethylphthalimide

HRID 597259

Reaction equation

HRID 597259 reaction equation
[ClH:1].O[CH2:3][N:4]1[C:8](=[O:9])[C:7]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:6]2[C:5]1=[O:14]>>[Cl:1][CH2:3][N:4]1[C:8](=[O:9])[C:7]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:6]2[C:5]1=[O:14]

Participants

3

Reactant 2

HCID 313Hydrochloric Acid3×HCID 8354N-(hydroxymethyl)phthalimide

Product 1

HCID 87154Chloromethylphthalimide

Procedure

reacting said mixture at a temperature of from about 45° to about 75° C at a pressure of from about 0 psig to about 50 psig while intimately contacting said reacting mixture with anhydrous HCl at a rate of from approximately 15 to approximately 65 pounds HCl per hour per pound-mole of N-hydroxymethyl phthalimide used to form the mixture in step (a), to maintain the concentration of said aqueous HCl at 35 to 40 wt.%, to form N-chloromethyl phthalimide in an aqueous-organic mixture;

Workup

  1. customof from about 45° to about 75° C
  2. customto form the mixture in step (a)

Sources & evidence

ORD record
ord-5a6163d7f1c243ed9c96af6ef0a01adf
Source dataset
uspto-grants-1977_03
Patent number
US04013685

Linked notes

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