Hydrochloric Acid → (7-Chloro-quinazolin-2-yl)-pyrrolidin-3-yl-amine

HRID 598507

Reaction equation

HRID 598507 reaction equation
ClC1C=CC2N=C([NH:9][CH:10]3[CH2:14][CH2:13][NH:12][CH2:11]3)OC=2C=1.Cl.Cl[C:19]1[N:28]=[CH:27][C:26]2[C:21](=[CH:22][C:23]([Cl:29])=[CH:24][CH:25]=2)[N:20]=1.C(OC(N1CCC(N)C1)=O)(C)(C)C>>[Cl:29][C:23]1[CH:22]=[C:21]2[C:26]([CH:27]=[N:28][C:19]([NH:9][CH:10]3[CH2:14][CH2:13][NH:12][CH2:11]3)=[N:20]2)=[CH:25][CH:24]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 27563701-Boc-3-aminopyrrolidineHCID 124139292,7-DichloroquinazolineHCID 57748894(6-Chloro-benzooxazol-2-yl)-pyrrolidin-3-yl-amine

Product 1

HCID 57748884(7-Chloro-quinazolin-2-yl)-pyrrolidin-3-yl-amine

Procedure

In analogy to the procedure described for the synthesis of (6-Chloro-benzooxazol-2-yl)-pyrrolidin-3-yl-amine; hydrochloride (example 1, step 1) the title compound was prepared from 2,7-dichloro-quinazoline (Synthesis 1978, 5, 379-82) and 3-Amino-pyrrolidine-1-carboxylic acid tert-butyl ester (commercially available) and subsequent cleavage of the tert-butyl oxy carbonyl protecting group under acidic conditions. (MH+) 249.1.

Sources & evidence

ORD record
ord-57484053289b46ad9525737d07091ee3
Source dataset
uspto-grants-2011_03
Patent number
US07897627B2

Linked notes

Loading…