Sodium hydride → HCID 178498783, compound
Reaction equation
Cl[C:2]1[C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][N:5]=[CH:4][C:3]=1[C:12]([O:14]C)=O.C(O)(=O)C.[CH:20](=[NH:22])[NH2:21].[H-].[Na+]>O1CCOCC1>[OH:14][C:12]1[C:3]2[CH:4]=[N:5][CH:6]=[C:7]([C:8]([O:10][CH3:11])=[O:9])[C:2]=2[N:21]=[CH:20][N:22]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To the mixture of dimethyl 4-chloropyridine-3,5-dicarboxylate (0.6 g, 2.6 mmol) and formimidamide acetate (0.82 g, 7.8 mmol) in dioxane (20 mL) was added NaH (0.31 g, 7.8 mmol). The resulting mixture was refluxed for 48 hours, cooled to RT. The precipitate was filtered, and washed with EA to afford the title compound as grey solid (yield 56.1%).
Workup
- temperatureThe resulting mixture was refluxed for 48 hours
- filtrationThe precipitate was filtered
- washwashed with EA
Sources & evidence
- ORD record
- ord-d8e04bf101054bd485f02b6b7bb4af81
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09440968B2
Reaction notes
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