Ammonium Hydroxide → HCID 178513742, compound
Reaction equation
[OH:1][C:2]1[C:3]2[CH:11]=[N:10][CH:9]=[C:8]([C:12]([O:14]C)=O)[C:4]=2[N:5]=[CH:6][N:7]=1.[NH4+:16].[OH-]>CO>[OH:1][C:2]1[C:3]2[CH:11]=[N:10][CH:9]=[C:8]([C:12]([NH2:16])=[O:14])[C:4]=2[N:5]=[CH:6][N:7]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The mixture of methyl 4-hydroxypyrido[4,3-d]pyrimidine-8-carboxylate (47 mg, 0.1 mmol), NH4OH (3 mL) and MeOH (10 mL) was heated to reflux for 20 hours in a sealed tube. The mixture was then concentrated and purified by prep-HPLC to afford the title compound as a white solid (yield 41.1%).
Workup
- temperaturewas heated
- temperatureto reflux for 20 hours in a sealed tube
- concentrationThe mixture was then concentrated
- custompurified by prep-HPLC
Sources & evidence
- ORD record
- ord-1832a42924764ce6af2fccc537584134
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09440968B2
Reaction notes
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