Ethanol → acryloyl-CoA

HRID 600169

Reaction equation

HRID 600169 reaction equation
[C:1]([S:4][CH2:5][CH2:6][NH:7][C:8](=[O:51])[CH2:9][CH2:10][NH:11][C:12](=[O:50])[C@H:13]([OH:49])[C:14]([CH3:48])([CH3:47])[CH2:15][O:16][P:17]([OH:46])(=[O:45])[O:18][P:19]([OH:44])(=[O:43])[O:20][CH2:21][C@H:22]1[O:26][C@@H:25]([N:27]2[C:36]3[N:35]=[CH:34][N:33]=[C:31]([NH2:32])[C:30]=3[N:29]=[CH:28]2)[C@H:24]([OH:37])[C@@H:23]1[O:38][P:39]([OH:42])([OH:41])=[O:40])(=[O:3])[CH3:2].[CH2:52](O)C.C(OCC)(=O)C=C>O>[C:1]([S:4][CH2:5][CH2:6][NH:7][C:8](=[O:51])[CH2:9][CH2:10][NH:11][C:12](=[O:50])[C@H:13]([OH:49])[C:14]([CH3:47])([CH3:48])[CH2:15][O:16][P:17]([OH:46])(=[O:45])[O:18][P:19]([OH:44])(=[O:43])[O:20][CH2:21][C@H:22]1[O:26][C@@H:25]([N:27]2[C:36]3[N:35]=[CH:34][N:33]=[C:31]([NH2:32])[C:30]=3[N:29]=[CH:28]2)[C@H:24]([OH:37])[C@@H:23]1[O:38][P:39]([OH:42])([OH:41])=[O:40])(=[O:3])[CH:2]=[CH2:52]

Participants

5

Reactant 3

HCID 702EthanolHCID 8821Ethyl AcrylateHCID 444493acetyl CoA

Product 1

HCID 9543026acryloyl-CoA

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of acrylyl coenzyme A is prepared at a concentration of 890 ppm following a similar method to that outlined in Example 1a but prepared in water and using one third the amount of S-acetyl coenzyme A synthetase. To this, 44 mg/mL of ethanol and 100 mg/mL of Novozym 435 are added following example 1b. After 2 hours at 37° C. the concentration of ethyl acrylate is found to be 16.4 ppm.

Sources & evidence

ORD record
ord-17d96c466b8f4c7d9ae931a6c90d450b
Source dataset
uspto-grants-2011_03
Patent number
US07901915B2

Linked notes

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