Hydrochloric Acid → (1R,2R)-1-Amino-2-phenylcyclopropane-1-carboxylic acid hydrochloride
Reaction equation
[NH2:1][C@:2]1([C:11]([O:13]C)=[O:12])[CH2:4][C@@H:3]1[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[ClH:15]>O>[ClH:15].[NH2:1][C@:2]1([C:11]([OH:13])=[O:12])[CH2:4][C@@H:3]1[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of (1R,2R)-methyl 1-amino-2-phenylcyclopropanecarboxylate (14 mg), water (4 mL) and hydrochloric acid (37% w/v, 6 mL) was heated under reflux for 6 h. The mixture was evaporated to dryness, triturated with diethyl ether and the solid collected and dried to give the subtitle compound (14 mg) as a colourless solid.
Workup
- temperaturewas heated
- temperatureunder reflux for 6 h
- customThe mixture was evaporated to dryness
- customtriturated with diethyl ether
- customthe solid collected
- customdried
Sources & evidence
- ORD record
- ord-2697ca3dc3ed4943a0c8c5e28b7f541c
- Source dataset
- uspto-grants-2011_03
- Patent number
- US07902181B2
Reaction notes
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