Ammonium Hydroxide → HCID 15864348, compound

Reaction equation

[NH2:1][C:2]1[C:7]([S:8](Cl)(=[O:10])=[O:9])=[CH:6][C:5]([CH3:12])=[CH:4][N:3]=1.[OH-].[NH4+:14]>>[NH2:1][C:2]1[C:7]([S:8]([NH2:14])(=[O:10])=[O:9])=[CH:6][C:5]([CH3:12])=[CH:4][N:3]=1

Participants

Reactant 2

HCID 14923Ammonium Hydroxide

HCID 189487872-aMino-5-Methylpyridine-3-sulfonyl chloride

Product 1

HCID 15864348HCID 15864348, compound

Procedure

The product of Example 104A was reacted with concentrated ammonium hydroxide at ambient temperature overnight. The reaction mixture was concentrated to give the title compound as a light yellow solid in quantitative yield. MS (DCI/NH3) m/z 188 (M+H)+. 1H NMR (300 MHz, DMSO-d6) δ 2.17 (m, 3H), 6.28 (s, 2H), 7.43 (s, 2H), 7.70 (d, J=1.84 Hz, 1H), 8.00 (d, J=2.21 Hz, 1H).

Workup

concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record: ord-1509d5ad77c547238f72ebc85086f684
Source dataset: uspto-grants-2011_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07902203B2

Reaction notes

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