2-Amino-5-bromobenzenesulfonamide → N-[2-(aminosulfonyl)phenyl]-4-hydroxy-2-oxo-1-propoxy-1,2-dihydroquinoline-3-carboxamide

HRID 601166

Reaction equation

HRID 601166 reaction equation
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]([O:12][CH2:13][CH2:14][CH3:15])[C:4](=[O:16])[C:3]=1[C:17]([O:19]CC)=O.C(N1C2C(=CC=CN=2)C(O)=C(C(OCC)=O)C1=O)C1C=CC=CC=1.[NH2:46][C:47]1[CH:52]=[CH:51][C:50](Br)=[CH:49][C:48]=1[S:54]([NH2:57])(=[O:56])=[O:55]>>[NH2:57][S:54]([C:48]1[CH:49]=[CH:50][CH:51]=[CH:52][C:47]=1[NH:46][C:17]([C:3]1[C:4](=[O:16])[N:5]([O:12][CH2:13][CH2:14][CH3:15])[C:6]2[C:11]([C:2]=1[OH:1])=[CH:10][CH:9]=[CH:8][CH:7]=2)=[O:19])(=[O:55])=[O:56]

Participants

4

Reactant 3

HCID 8207002-Amino-5-bromobenzenesulfonamideHCID 54729304Ethyl 1-benzyl-4-hydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylateHCID 67063576Ethyl 4-hydroxy-2-oxo-1-propoxy-1,2-dihydroquinoline-3-carboxylate

Product 1

HCID 67063695N-[2-(aminosulfonyl)phenyl]-4-hydroxy-2-oxo-1-propoxy-1,2-dihydroquinoline-3-carboxamide

Procedure

The title compound is prepared according to the procedure of Example 84C substituting the product of Example 172D for the product of Example 84B and substituting 2-aminosulfonamide for the product of Example 84A.

Sources & evidence

ORD record
ord-24a914d39abf45a7a65cd0da851c6378
Source dataset
uspto-grants-2011_03
Patent number
US07902203B2

Linked notes

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