2,6-Dichlorophenol → N-(2',6'-dichlorophenyl)-N-chloroacetyl-4-methylaniline

HRID 603352

Reaction equation

HRID 603352 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1O.[Cl:10][CH2:11][C:12]([NH:14][C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][CH:16]=1)=[O:13]>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:14]([C:12](=[O:13])[CH2:11][Cl:10])[C:15]1[CH:16]=[CH:17][C:18]([CH3:21])=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 68992,6-DichlorophenolHCID 279672-Chloro-N-(4-methylphenyl)acetamide

Product 1

HCID 57952147N-(2',6'-dichlorophenyl)-N-chloroacetyl-4-methylaniline

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Same procedure as example 6a starting from 2,6-dichlorophenol and 2-chloro-N-(4-methylphenyl)acetamide. At the end of the acetylation reaction the mixture was diluted with a small amount of toluene (0.2 part) to prevent solidification.

Workup

  1. customAt the end of the acetylation reaction the mixture

Sources & evidence

ORD record
ord-af3bd9ab2c584e5988f942de2ef192e8
Source dataset
uspto-grants-2011_03
Patent number
US07906677B2

Linked notes

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