2-Chlorobenzothiazole → 2-Benzothiazolyl 3-piperidinopropyl ether
Reaction equation
[N:1]1([CH2:7][CH2:8][CH2:9][O-:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Na+].Cl[C:13]1[S:14][C:15]2[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=2[N:17]=1>O1CCCC1>[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:13]2[S:14][C:15]3[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=3[N:17]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Sodium 3-piperidinopropanolate (5 mmol) and 5 mmol of 2-chlorobenzothiazole in 20 ml of dry tetrahydrofurane were refluxed for 12 hours. The suspension was filtered and the solvent evaporated under reduced pressure. The product was crystallized with oxalic acid from diethyl ether/ethanol.
Workup
- filtrationThe suspension was filtered
- customthe solvent evaporated under reduced pressure
- customThe product was crystallized with oxalic acid from diethyl ether/ethanol
Sources & evidence
- ORD record
- ord-aa97bd1dfcb1454d9bb914ada6e17f53
- Source dataset
- uspto-grants-2011_03
- Patent number
- US07910605B2
Reaction notes
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