Water → 2-Chloro-N-methoxy-N-methylbenzamide
Reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].Cl.[CH3:12][O:13][NH:14][CH3:15].C(N(CC)CC)C.O>C(Cl)Cl>[Cl:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([N:14]([O:13][CH3:12])[CH3:15])=[O:5]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
50 ml of 2-chlorobenzoyl chloride are added slowly to a mixture of 37.33 g of N-methoxymethanamine hydrochloride and 104 ml of triethylamine in 500 ml of DCM and the mixture is left to stir overnight at AT. Water is added to the reaction mixture, the mixture is extracted with DCM, the organic phase is washed with a buffer solution pH=2 and dried over Na2SO4, and the solvent is evaporated off under vacuum. 78.57 g of the expected compound are obtained.
Workup
- waitthe mixture is left
- extractionthe mixture is extracted with DCM
- washthe organic phase is washed with a buffer solution pH=2
- dry with materialdried over Na2SO4
- customthe solvent is evaporated off under vacuum
Sources & evidence
- ORD record
- ord-a2d3bd84d52348c9bdfe9e1ff8be64cf
- Source dataset
- uspto-grants-2011_03
- Patent number
- US07915258B2
Reaction notes
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