HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Methyl-2-(pyridin-4-yl)benzoic acid hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 5-methyl-2-(pyridin-4-yl)benzoate | HCID 86680841 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-Methyl-2-(pyridin-4-yl)benzoic acid hydrochloride | HCID 86680842 | — |
Reaction Steps
A mixture of methyl 5-methyl-2-(pyridin-4-yl)benzoate (8.8 g), 6 N hydrochloric acid (65 mL) and acetic acid (100 mL) was heated under reflux overnight. The solvent was evaporated under reduced pressure, and the obtained solid was washed with ethyl acetate to give the title compound (6.6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09440990B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-af2844a64cfa403e89abd8269f3bd4d6 |
| Source note | uspto-grants-2016_09 |