Hydrochloric Acid → 3-Methyl-5-phenylethynylpyridine hydrochloride
Reaction equation
[ClH:1].[CH3:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([C:9]#[C:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:8]=1>O1CCOCC1.C(OCC)C>[ClH:1].[CH3:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([C:9]#[C:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:8]=1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
Add a 4 N solution of hydrogen chloride in 1,4-dioxane (0.6 mL) to a solution of 3-methyl-5-phenylethynylpyridine (0.398 g, 2.06 mmol), (prepared essentially as described in EXAMPLE 1), in diethyl ether (2 mL). Concentrate the reaction mixture and triturate the resulting solid with hexanes and diethyl ether to give the title compound as a solid (0.477 mg, 100%).
Workup
- custom(prepared essentially
- concentrationConcentrate the reaction mixture
- customtriturate the resulting solid with hexanes and diethyl ether
Sources & evidence
- ORD record
- ord-5ce516976ecf47aeacdc404f9ef9b176
- Source dataset
- uspto-grants-2011_03
- Patent number
- US07915424B2
Reaction notes
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