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Triethylamine → methanesulfonic acid Trans-2-benzhydryl-tetrahydropyran-4-yl ester

HRID 606963
Notes
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Reaction equation

HRID 606963 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[CH:6]([C@H:19]1[CH2:24][C@H:23]([OH:25])[CH2:22][CH2:21][O:20]1)([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.C(N(CC)CC)C>C(Cl)Cl>[CH:6]([C@H:19]1[CH2:24][C@H:23]([O:25][S:2]([CH3:1])(=[O:4])=[O:3])[CH2:22][CH2:21][O:20]1)([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1
ParticipantsConditionsProcedureWorkupSources & evidenceReaction notes

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 66631792trans-2-Benzhydryl-tetrahydropyran-4-ol

Product 1

HCID 86605343methanesulfonic acid Trans-2-benzhydryl-tetrahydropyran-4-yl esterYield 99.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent3×

Conditions

Temperature
0 °C

Procedure

Methanesulfonyl chloride (0.62 g, 5.41 mmol) in dry methylene chloride (10 ml) was added dropwise to a mixture of trans-2-diphenylmethyl-4-hydroxypyran 3a (0.73 g, 2.70 mmol), triethylamine (0.41 g, 4.06 mmol) in methylene chloride (10 ml) and was cooled to 0° C. After one hour, the reaction was gradually allowed to reach room temperature over a period of four hours. Additional methylene chloride (20 ml) was added to the reaction mixture, and the mixture was washed in turn with saturated aqueous sodium bicarbonate, brine and water, then dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure, and purification by flash chromatography gave compound 4a (0.93 g, 99.9% yield) as an oil.

Workup

  1. waitto reach room temperature over a period of four hours
  2. washthe mixture was washed in turn with saturated aqueous sodium bicarbonate, brine and water
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was removed under reduced pressure, and purification by flash chromatography

Sources & evidence

ORD record
ord-b1f97f55fa7d4c5e84b1c8cc3fd0d263
Source dataset
uspto-grants-2011_03
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US07915433B2

Reaction notes

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On this pageParticipantsConditionsProcedureWorkupSources & evidenceReaction notes