2-Methoxypyrimidine-5-boronic acid → 2-(2-Methoxypyrimidin-5-yl)-5-methylbenzoic acid

Reaction equation

[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:11]2[CH:12]=[N:13][N:14]([CH3:16])[CH:15]=2)=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[CH3:17][O:18]C1N=CC(B(O)O)=CN=1>>[CH3:17][O:18][C:16]1[N:13]=[CH:12][C:11]([C:5]2[CH:4]=[CH:3][C:2]([CH3:1])=[CH:10][C:6]=2[C:7]([OH:9])=[O:8])=[CH:15][N:14]=1

Participants

Reactant 2

HCID 27367782-Methoxypyrimidine-5-boronic acid

HCID 811115005-Methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoic acid

Product 1

HCID 1127475912-(2-Methoxypyrimidin-5-yl)-5-methylbenzoic acid

Procedure

The title compound was synthesized following the same general protocol as described for 5-methyl-2-(1-methyl-1H-pyrazol-4-yl)benzoic acid in Example A1, using (2-methoxypyrimidin-5-yl)boronic acid. ESI-MS (m/z): 245 [M+1]+.

Sources & evidence

ORD record: ord-c0161b62e28340f98b88ab0f4c309424
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09440982B2

Reaction notes

Loading…