N-(2-Aminoethyl)piperidine → N-[2-(1-Piperidyl)ethyl] 1H-indole-3-carboxamide
Reaction equation
[N:1]1([CH2:7][CH2:8][NH2:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[C:12]([C:19](Cl)=[O:20])=[CH:11]1>>[N:1]1([CH2:7][CH2:8][NH:9][C:19]([C:12]2[C:13]3[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=3)[NH:10][CH:11]=2)=[O:20])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1Participants
3
Procedure
1-Piperidineethylamine was reacted with 1H-indole-3-carboxylic acid chloride using the method described in Description 1 to afford the title compound (D2) as a beige solid.
Sources & evidence
- ORD record
- ord-1a878120141342c99d35bd80246da004
- Source dataset
- uspto-grants-1999_12
- Patent number
- US05998409
Reaction notes
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