Phenylhydrazine → 1-(3-Bromophenyl)-3-methyl-1H-pyrazole

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([NH:8][NH2:9])[CH:5]=[CH:6][CH:7]=1.[C:10]1(NN)[CH:15]=CC=[CH:12][CH:11]=1>>[Br:1][C:2]1[CH:3]=[C:4]([N:8]2[CH:15]=[CH:10][C:11]([CH3:12])=[N:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 7516Phenylhydrazine

HCID 33758(3-Bromophenyl)hydrazine

Product 1

HCID 179399391-(3-Bromophenyl)-3-methyl-1H-pyrazole

Procedure

This compound was prepared by the same methodology described for EXAMPLE 1 with 3-bromophenyl hydrazine · HCl substituted for phenyl hydrazine. There was obtained 1-(3-bromophenyl)-3-methyl-1H-pyrazole-5-[(2'-aminosulfonyl-[1,1']-biphen-4-yl)carboxyamide; HRMS(M+H)+ calc. 511.043949; found: 511.043295.

Workup

customThis compound was prepared by the same methodology

Sources & evidence

ORD record: ord-8f514d05ff514f33a4e81e55adc9a986
Source dataset: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05998424

Reaction notes

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