Hydrochloric Acid → 8-phenoxyoctanoic Acid

HRID 611661Notes

Reaction equation

HRID 611661 reaction equation
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].Br[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19].Cl>CCO.O>[O:7]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 996PhenolHCID 14798Sodium HydroxideHCID 5482758-Bromooctanoic acid

Product 1

HCID 102203288-phenoxyoctanoic AcidYield 76%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

Phenol (1.88 g, 20 mmol) was mixed with NaOH (0.80 g, 20 mmol) in EtOH (50 mL). 8-Bromooctanoic acid (2.23 g, 10 mmol) was then added to the mixture and refluxed for 12 h. After cooling to room temperature, water (100 mL) was added and the mixture was acidified with 2N HCl (pH=2). The solid was filtered and washed with water (2×50 mL), and recrystallized from hexane-ethyl acetate (5:1) to give the product as white brick-like crystals (1.79 g, 76%), mp 67-68° C.; 1H-NMR: 1.42 (m, 6 H), 1.65 (m, 2 H), 1.80 (m, 2 H), 2.37 (t, 2 H), 3.97 (t, 2 H), 6.93 (m, 3 H), 7.30 (t, 2 H), 10.05 (bs, 1 H). Anal. Calcd. for C14H20O3 : C, 71.16, H, 8.53%; Found: C, 71.09, H, 8.54%.

Workup

  1. temperaturerefluxed for 12 h
  2. filtrationThe solid was filtered
  3. washwashed with water (2×50 mL)
  4. customrecrystallized from hexane-ethyl acetate (5:1)

Sources & evidence

ORD record
ord-06875566834849a3bc55cdedd745eb16
Source dataset
uspto-grants-1999_12
Patent number
US06001869

Reaction notes

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