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4-Methylmorpholine → t-Butyl (6R,7R)-7-Amino-3-[(RS)-tetrahydrofuran-3-yl]ceph-3-em-4-carboxylate

HRID 612292
Notes
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Reaction equation

HRID 612292 reaction equation
C1(CC([NH:10][C@@H:11]2[C:30](=[O:31])[N:13]3[C:14]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])=[C:15]([CH:18]4[CH2:22][CH2:21][O:20][CH2:19]4)[CH2:16][S:17][C@H:12]23)=O)C=CC=CC=1.CN1CCOCC1.P(Cl)(Cl)(Cl)(Cl)Cl>ClCCl.CO.O>[NH2:10][C@@H:11]1[C:30](=[O:31])[N:13]2[C:14]([C:23]([O:25][C:26]([CH3:27])([CH3:28])[CH3:29])=[O:24])=[C:15]([CH:18]3[CH2:22][CH2:21][O:20][CH2:19]3)[CH2:16][S:17][C@H:12]12
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

7

Reactant 3

HCID 79724-MethylmorpholineHCID 24819Phosphorus pentachlorideHCID 54439270t-Butyl (6R,7R)-7-Phenylacetamido-3-[(RS)-tetra-hydrofuran-3-yl]ceph-3-em-4-carboxylate

Product 1

HCID 54127982t-Butyl (6R,7R)-7-Amino-3-[(RS)-tetrahydrofuran-3-yl]ceph-3-em-4-carboxylate

Reagents, catalysts & solvents 3

HCID 887Methanol
Solvent
HCID 962WaterSolvent
HCID 6344DichloromethaneSolvent2×

Procedure

t-Butyl (6R,7R)-7-phenylacetamido-3-[(RS)-tetrahydrofuran-3-yl]ceph-3-em-4-carboxylate (0.9 g) in dichloromethane (15 ml) with N-methylmorpholine (0.45 g, 0.49 ml) was successively treated with phosphorus pentachloride (0.549 g) in dichloromethane (13.74 ml), methanol (10 ml) and water (10 ml) as described in Example 2(f). After purification by flash chromatography on silica gel eluting with 60, 80% ethyl acetate/hexane and then ethyl acetate, the title compound was obtained as a yellow solid (0.481 g, 73%); (Found: M+, 326.1304. C15H22N2O4S requires M, 326.1300); νmax (CH2Cl2) 3408, 1775 and 1716 cm-1 ; δH (CDCl3) 1.55 (9 H, s), 1.69-2.41 (3 H, m's), 3.31 and 3.48 with 3.34 and 3.49 (2 H, 2ABq's, J 17.5 and 17.5 Hz), 3.69-3.83 (4 H, 2 s's overlapping m), 3.97-4.05 (2 H, m), 4.72 and 4.74 (1 H, 2 d's, J 4.3 and 4.4 Hz) and 4.95 and 4.97 (1 H, 2 d's, J 4.3 and 4.4 Hz).

Workup

  1. customAfter purification by flash chromatography on silica gel eluting with 60, 80% ethyl acetate/hexane

Sources & evidence

ORD record
ord-40517d2fb2f04b8a948e735b0a4e0d4f
Source dataset
uspto-grants-1999_12
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US06001997

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes