Hydrochloric Acid → D-phenylalanine hydrochloride

HRID 613796

Reaction equation

HRID 613796 reaction equation
[NH2:1][C@@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[ClH:13]>>[ClH:13].[NH2:1][C@@H:2]([C:10]([OH:12])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 71567D-Phenylalanine

Product 1

HCID 13000988D-phenylalanine hydrochloride

Procedure

The residual mother liquor weighing 1359 g which contained 185.6 mmol of D-phenylalanine having an optical purity of 93.6% was adjusted to pH 0.5 with concentrated hydrochloric acid, and the resulting solution was concentrated until crystals began to precipitate to carry out crystallization. The aqueous slurry containing the crystals was filtered by suction at room temperature to give 74.8 mmol of glossy and grayish crystals of D-phenylalanine hydrochloride having an optical purity of 99.2%. The mother liquor contained 110.8 mmol of D-phenylalanine having an optical purity of 89.7%.

Workup

  1. concentrationthe resulting solution was concentrated until crystals
  2. customto precipitate
  3. customcrystallization
  4. additionThe aqueous slurry containing the crystals
  5. filtrationwas filtered by suction at room temperature

Sources & evidence

ORD record
ord-5ac1dc546b954f75a397be33b350b0c6
Source dataset
uspto-grants-1999_12
Patent number
US06008403

Linked notes

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