Benzene → 2-(4-Methylpiperazin-1-yl)propanenitrile

HRID 614477

Reaction equation

HRID 614477 reaction equation
[C:1](#[N:5])[CH:2]([CH3:4])O.[CH3:6][N:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1.C1C=CC=CC=1>O>[CH3:6][N:7]1[CH2:12][CH2:11][N:10]([CH:2]([CH3:4])[C:1]#[N:5])[CH2:9][CH2:8]1

Participants

5

Reactant 3

HCID 241BenzeneHCID 6572LactonitrileHCID 531671-Methylpiperazine

Product 1

HCID 213278122-(4-Methylpiperazin-1-yl)propanenitrile

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Lactonitrile (71.08 g.) is added in a dropwise manner to a stirred solution of 100.1 g. of 1-methyl-piperazine in 500 ml. of benzene. The resulting warm solution is heated at reflux under a water separator until the theoretical amount of water is collected (about 4 hours). The solution is evaporated at reduced pressure and the residue is fractionated. The product, 2-(4-methyl-1-piperazinyl)propionitrile, is obtained as an oil, b.p. 128°-130° C./23 mm.

Workup

  1. temperatureThe resulting warm solution
  2. temperatureis heated
  3. customis collected (about 4 hours)
  4. customThe solution is evaporated at reduced pressure

Sources & evidence

ORD record
ord-7d3b2c2e128b4aaf9cc79588b1c29495
Source dataset
uspto-grants-1979_03
Patent number
US04145347

Linked notes

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