Diisopropylamine → HCID 13272378, compound

HRID 615396

Reaction equation

HRID 615396 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[C:10]([C:18](O)=[O:19])[N:9]=1.ClC(OCC)=O.[CH:27]([NH:30][CH:31]([CH3:33])[CH3:32])([CH3:29])[CH3:28]>C(N(CC)CC)C>[CH3:28][CH:27]([N:30]([CH:31]([CH3:33])[CH3:32])[C:18]([C:10]1[N:9]=[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[C:17]2[C:12]([CH:11]=1)=[CH:13][CH:14]=[CH:15][CH:16]=2)=[O:19])[CH3:29]

Participants

5

Reactant 3

HCID 7912DiisopropylamineHCID 10928Ethyl chloroformateHCID 110005543-Isoquinolinecarboxylicacid, 1-(2-chlorophenyl)-

Product 1

HCID 13272378HCID 13272378, compoundYield 23.2%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Operations are carried out as for Example 7, starting from 2.83 g of 1-(2-chloro phenyl) isoquinoline 3-carboxylic acid, 1.17 g of triethylamine, 1.25 g of ethyl chloroformate and 1.31 g of di-isopropylamine in 100 ml of chlorofom. 0.85 g of N,N-di(1-methyl ethyl) 1-(2-chloro phenyl) isoquinoline 3-carboxamide, melting at 161° C., is obtained.

Sources & evidence

ORD record
ord-782300f7520f40ef882ecfdb198c7fef
Source dataset
uspto-grants-1985_02
Patent number
US04499094

Linked notes

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