Sodium Hydroxide → Pentiapine

HRID 615566

Reaction equation

HRID 615566 reaction equation
[C:1]([N:6]1[CH2:11][CH2:10][N:9]([C:12]2[N:13]3[CH:25]=[CH:24][N:23]=[C:14]3[S:15][C:16]3[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=3[N:18]=2)[CH2:8][CH2:7]1)(OCC)=O.[H-].[Li+].[OH-].[Na+]>O1CCCC1>[CH3:1][N:6]1[CH2:11][CH2:10][N:9]([C:12]2[N:13]3[CH:25]=[CH:24][N:23]=[C:14]3[S:15][C:16]3[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=3[N:18]=2)[CH2:8][CH2:7]1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 62714Lithium hydrideHCID 131782745-(4-Carboethoxypiperazino)-imidazo[2,1-b][1,3,5]benzothiadiazepine

Product 1

HCID 54742Pentiapine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To the solution of 0.2 g of 5-(4-carboethoxypiperazino)-imidazo[2,1-b][1,3,5]benzothiadiazepine in 2 ml of dry tetrahydrofuran, 100 mg of lithium hydride are added at once and the mixture is refluxed under nitrogen for 48 hrs. The mixture is cooled to room temperature, stirred with 0.2 ml of pb 30% sodium hydroxide, and filtered. The filtrates were evaporated to dryness and the product is purified to give 5-(4-methylpiperazino]-imidazo[2,1-b][1,3,5]benzothiadiazepine, melting at 145°-147°, and identical to compound obtained in example 1.

Workup

  1. temperatureis refluxed under nitrogen for 48 hrs
  2. filtrationfiltered
  3. customThe filtrates were evaporated to dryness
  4. customthe product is purified

Sources & evidence

ORD record
ord-81d50e1b0f144953869aaeb0b436e3f3
Source dataset
uspto-grants-1985_02
Patent number
US04500472

Linked notes

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