2-Chloroethyldiisopropylammonium chloride → 2-Propanamine, N-(1-methylethyl)-N-(2-(2-(2-methylpropoxy)phenoxy)ethyl)-

HRID 616372Notes

Reaction equation

HRID 616372 reaction equation
[Na].[CH2:2]([O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[OH:13])[CH:3]([CH3:5])[CH3:4].Cl.[CH:15]([N:18]([CH2:22][CH2:23]Cl)[CH:19]([CH3:21])[CH3:20])([CH3:17])[CH3:16]>C(O)C>[CH2:2]([O:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[O:13][CH2:23][CH2:22][N:18]([CH:19]([CH3:21])[CH3:20])[CH:15]([CH3:17])[CH3:16])[CH:3]([CH3:5])[CH3:4]

Participants

5

Reactant 3

HCID 779422-Chloroethyldiisopropylammonium chlorideHCID 6911612-IsobutoxyphenolHCID 5360545Sodium

Product 1

HCID 30426732-Propanamine, N-(1-methylethyl)-N-(2-(2-(2-methylpropoxy)phenoxy)ethyl)-

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The compound was prepared as described in Example 1, using sodium (3.45 g; 150 mmole), o-isobutoxyphenol (12.45 g; 75 mmole) and diisopropylaminoethylchloride hydrochloride (15.0 g; 75 mmole) in 200 ml of ethanol. Yield 11.2 g (51%) of product, boiling at 111°-113° C under a pressure of 0.001 mm.Hg, nD25 : 1.4920.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-d9826df901224041ac2bf5f085253604
Source dataset
uspto-grants-1978_02
Patent number
US04073917

Reaction notes

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