HCID 20368146, compound → 1H-1,4-Benzodiazepine

HRID 616664

Reaction equation

HRID 616664 reaction equation
F[C:2]1[CH:3]=[CH:4][C:5]2[N:11]3C(C)=NN=[C:10]3[CH2:9][N:8]=[C:7](C3C=CC=CC=3F)[C:6]=2[CH:23]=1>CN(C)C=O.C(Cl)(=O)C>[NH:11]1[C:5]2[CH:4]=[CH:3][CH:2]=[CH:23][C:6]=2[CH:7]=[N:8][CH:9]=[CH:10]1

Participants

4

Reactant 1

HCID 20368146HCID 20368146, compound

Product 1

HCID 1484311H-1,4-Benzodiazepine

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 6367Acetyl chlorideSolvent

Procedure

In the manner given in Example 1, a solution of 8-fluoro-1-methyl-6-(o-fluorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine in dimethylformamide, N,N,N',N'-tetrapropyldiaminomethane and acetyl chloride (in 0.5 molar excess compared to the N,N,N',N'-tetrapropyldiaminomethane) are reacted together to give 8-fluoro-1[2-(dipropylamino)ethyl]-6-(o-fluorophenyl)-4H-s-triazolo[4,3-a][1,4-benzodiazepine

Workup

  1. customare reacted together

Sources & evidence

ORD record
ord-e375e263f104480eb2604e29d92efb05
Source dataset
uspto-grants-1978_02
Patent number
US04075221

Linked notes

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