2-Bromopyrimidine → 6,6-Dimethyl-11-oxo-8-(pyrimidin-2-yloxy)-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

HRID 61713

Reaction equation

HRID 61713 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][C:5]2[C:17](=[O:18])[C:16]3[C:15]4[C:10](=[CH:11][C:12]([C:19]#[N:20])=[CH:13][CH:14]=4)[NH:9][C:8]=3[C:7]([CH3:22])([CH3:21])[C:6]=2[CH:23]=1.Br[C:25]1[N:30]=[CH:29][CH:28]=[CH:27][N:26]=1>>[CH3:22][C:7]1([CH3:21])[C:8]2[NH:9][C:10]3[C:15](=[CH:14][CH:13]=[C:12]([C:19]#[N:20])[CH:11]=3)[C:16]=2[C:17](=[O:18])[C:5]2[CH:4]=[CH:3][C:2]([O:1][C:25]3[N:30]=[CH:29][CH:28]=[CH:27][N:26]=3)=[CH:23][C:6]1=2

Participants

3

Reactant 2

HCID 783452-BromopyrimidineHCID 668338618-Hydroxy-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

Product 1

HCID 668341036,6-Dimethyl-11-oxo-8-(pyrimidin-2-yloxy)-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

Procedure

Under the same conditions as the method for synthesizing Compound A7-17, the title compound was prepared from Compound A6 and 2-bromopyrimidine.

Workup

  1. customUnder the same conditions as the method for synthesizing Compound A7-17

Sources & evidence

ORD record
ord-1516b8de47314b2f849f64e9e744b18b
Source dataset
uspto-grants-2016_09
Patent number
US09440922B2

Linked notes

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