Hydrochloric Acid → 5-chloro-3-((1-methyl-(R)-pyrrolidinyl)methoxy)pyridine dihydrochloride

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([O:8][CH2:9][C@H:10]2[CH2:14][CH2:13][CH2:12][N:11]2[CH3:15])[CH:5]=[N:6][CH:7]=1.[ClH:16]>>[ClH:1].[ClH:16].[Cl:1][C:2]1[CH:3]=[C:4]([O:8][CH2:9][C@H:10]2[CH2:14][CH2:13][CH2:12][N:11]2[CH3:15])[CH:5]=[N:6][CH:7]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 541499775-chloro-3-((1-methyl-2-(R)-pyrrolidinyl)methoxy)pyridine

Product 1

HCID 702035245-chloro-3-((1-methyl-(R)-pyrrolidinyl)methoxy)pyridine dihydrochloride

Procedure

The compound of step 34a was treated with HCl as described in Example 1b and the title compound was isolated as a white powder. MS and 1H NMR (D2O, 300 Hz) are similar to 16b. Anal. Calc for C11H15N2OCl.2.00 HCl: C, 44.10; H, 5.20; N, 9.35; Found C, 43.98; H, 5.81; N, 9.33. [α]25D =+ 5.59° (c=1, MeOH).

Sources & evidence

ORD record: ord-01810c3b0b9c453dbd500c32d38c682d
Source dataset: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05948793

Reaction notes

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