Hydrochloric Acid → Ethyl thiophene-2-carboximidate hydrochloride
Reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]#[N:7].[ClH:8].[CH2:9]([OH:11])[CH3:10]>>[ClH:8].[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[NH:7])[O:11][CH2:9][CH3:10]Participants
4
Procedure
Ethyl 2-thiophenecarboximidate hydrochloride was synthesized in the same manner as in Reference Example 2. That is, 2-thiophenecarbonitrile (25.2 g, 0.231 mol) was treated with hydrogen chloride in ethanol (250 mL) to give 16.3 g (37%) of the target compound as colorless crystals.
Sources & evidence
- ORD record
- ord-80ce5be320a941bda7e49048bcaa9e1d
- Source dataset
- uspto-grants-1999_09
- Patent number
- US05948785
Reaction notes
Loading…