Dimethylformamide → 7-Methoxyheptanoic Acid

HRID 618300

Reaction equation

Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=[O:9].CN(C)[CH:13]=[O:14]>>[CH3:13][O:14][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([OH:10])=[O:9]

Participants

Reactant 2

HCID 6228Dimethylformamide

HCID 1217237-Bromoheptanoic acid

Product 1

HCID 154095287-Methoxyheptanoic Acid

Procedure

The title compound was prepared by the method of Example 1 using 7-bromoheptanoic acid (50 g, 239 mmol) instead of 12-bromoundecanoic acid and dimethylformamide (300 mL) instead of methanol as the solvent. Concentration afforded the title compound (30 g) as a pale yellow liquid and the structure verified by NMR.

Workup

concentrationConcentration

Sources & evidence

ORD record: ord-9f269605ad5e4ef8828b7ab218008c5e
Source dataset: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05952377

Linked notes

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