Hydrochloric Acid → 4,5-Dihydro-4[5-(amino)pentan-1-yl]-3h-1,4,8b-triazaacenaphthylen-5-one.dihydrochloride
Reaction equation
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][N:14]1[C:24](=[O:25])[C:23]2[N:26]3[C:16](=[CH:17][N:18]=[C:19]3[CH:20]=[CH:21][CH:22]=2)[CH2:15]1)=O)(C)(C)C.[ClH:27]>C(O)C>[ClH:27].[ClH:27].[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][N:14]1[C:24](=[O:25])[C:23]2[N:26]3[C:16](=[CH:17][N:18]=[C:19]3[CH:20]=[CH:21][CH:22]=2)[CH2:15]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 2.24 g (6.25 mmol) of 4,5-dihydro-4[5-(tert-butoxycarbonylamino)pentan-1-yl]-3H-1,4,8b-triazaacenaphthylen-5-one in 20 ml of ethanol was added 20 ml of conc. HCl. The mixture was stirred for 1.5 hour at room temperature. The solvent was distilled off to leave 2.05 g of the desired compound (quant. a pale brown solid). This product was used in the subsequent reaction without further purification. NMR(200 MHz,D2O)δ: 1.28-1.90(6H,m), 2.94(2H,t,J=7.2 Hz), 3.60(2H,t,J=7.2 Hz), 5.16(2H,s), 7.75(1H,s), 7.82-7.95(3H,m).