Piperidine → HCID 14306131, compound
Reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:7][O:8][CH2:9][C:10]1[N:15]=[C:14](Cl)[CH:13]=[CH:12][N:11]=1>ClCCl>[CH3:7][O:8][CH2:9][C:10]1[N:15]=[C:14]([N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)[CH:13]=[CH:12][N:11]=1Participants
4
Reagents, catalysts & solvents 1
Procedure
Piperidine (6.17 ml) in dichloromethane (40 ml) was added dropwise to a solution of 2-methoxymethyl-4-chloropyrimidine (4.71 g) in dichloromethane (40 ml). After standing overnight at room temperature the mixture was heated under reflux for 1 hour. After cooling the solution was washed with water, dried and stripped. The residue was chromatographed (silica gel, CHCl3) to give 2-methoxymethyl-4-piperidinopyrimidine (4.49 g) as an oil.
Workup
- temperaturethe mixture was heated
- temperatureunder reflux for 1 hour
- temperatureAfter cooling the solution
- washwas washed with water
- customdried
- customThe residue was chromatographed (silica gel, CHCl3)
Sources & evidence
- ORD record
- ord-6a8aafabc68745c0947343401412c0f0
- Source dataset
- uspto-grants-1989_04
- Patent number
- US04820708
Reaction notes
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