Reaction equation
[CH3:1][N:2]([CH3:7])[S:3](Cl)(=[O:5])=[O:4].[CH3:8][N:9]1[C:21]2[CH2:20][CH2:19][CH:18]([CH2:22][C:23]3[N:24]=[CH:25][NH:26][C:27]=3[CH3:28])[C:17](=[O:29])[C:16]=2[C:15]2[C:10]1=[CH:11][CH:12]=[CH:13][CH:14]=2.C(N(CC)CC)C.CCCCCC>ClCCl>[CH3:1][N:2]([CH3:7])[S:3]([N:26]1[C:27]([CH3:28])=[C:23]([CH2:22][CH:18]2[C:17](=[O:29])[C:16]3[C:15]4[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=4)[N:9]([CH3:8])[C:21]=3[CH2:20][CH2:19]2)[N:24]=[CH:25]1)(=[O:5])=[O:4]Participants
6
Procedure
A solution of dimethylsulphamoyl chloride (0.16 ml) in dry dichloromethane was added to a stirred solution of 1,2,3,9-tetrahydro-9-methyl-3-[(5-methyl-1H-imidazol-4-yl)methyl]-4H-carbazol-4-one (438 mg) and triethylamine (0.25 ml) in dry dichloromethane (30 ml) and the mixture was heated at reflux for 18 h. After cooling the reaction mixture was adsorbed onto FCC silica which was then applied to a column and FCC eluting with System A (150:8:1) gave an oil, which solidified to a powder on trituration with dry hexane (30 ml). This powder was then further purified by dissolution in dry dichloromethane (30 ml) and crystallisation by addition of dry hexane (10 ml) to give the title compound (518 mg), m.p. 122°-124°.
Workup
- temperaturethe mixture was heated
- temperatureat reflux for 18 h
- temperatureAfter cooling the reaction mixture
- washeluting with System A (150:8:1)
- customgave an oil, which
- customThis powder was then further purified by dissolution in dry dichloromethane (30 ml)
- customcrystallisation
- additionby addition of dry hexane (10 ml)
Sources & evidence
- ORD record
- ord-92df16e5fce8404c882045c4791a01ea
- Source dataset
- uspto-grants-1989_04
- Patent number
- US04822881
Linked notes
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