Ammonia → 5-bromo-3-chloro-2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridine

Temperature

-70 °C

In tetrahydrofuran (27 mL) was dissolved 5-bromo-3-chloro-N-methoxy-N-methylpyridine-2-carboxamide (2.66 g), the mixture was cooled under nitrogen atmosphere at −70° C. or lower, and a tetrahydrofuran (5 mL) suspension of lithium aluminum hydride (180 mg) was added dropwise to the mixture. The mixture was stirred at −70° C. or lower for 2 hours, then, water (10 mL) and a saturated brine (10 mL) were added dropwise to the mixture. A temperature of the mixture was raised to room temperature, the mixture was extracted with ethyl acetate, and the organic layer was washed with water and a saturated brine. The organic layer was dried over anhydrous magnesium sulfate, concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=100:0 to 90:10) to obtain a mixture of an aldehyde compound and an aldehyde equivalent (2.1 g). To water (36 mL) were added 3,3-dibromo-1,1,1-trifluoropropan-2-one (6.61 g) and sodium acetate (4.02 g) and the mixture was stirred at 95° C. for 30 minutes. An aqueous solution obtained by ice-cooling the mixture was added to a mixture comprising the previously obtained mixture of the aldehyde/aldehyde equivalent (1.8 g), 28% aqueous ammonia (18 mL) and methanol (36 mL) at room temperature, and the resulting mixture was stirred at room temperature for 17 hours. The reaction mixture was concentrated, the residue was extracted with ethyl acetate, and the organic layer was washed with a saturated brine, and then, dried over anhydrous magnesium sulfate. After concentrating the mixture under reduced pressure, the residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=80:20), and the obtained solid was collected by filtration, washed with isopropyl ether and dried to obtain 5-bromo-3-chloro-2-[5-(trifluoromethyl)-1H-imidazol-2-yl]pyridine (935 mg).

1. additionwas added dropwise to the mixture
2. temperatureA temperature of the mixture was raised to room temperature
3. extractionthe mixture was extracted with ethyl acetate
4. washthe organic layer was washed with water
5. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
6. concentrationconcentrated under reduced pressure
7. customthe residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=100:0 to 90:10)
8. customto obtain
9. stirringthe mixture was stirred at 95° C. for 30 minutes
10. customAn aqueous solution obtained by ice-
11. temperaturecooling the mixture
12. additionwas added to a mixture
13. stirringthe resulting mixture was stirred at room temperature for 17 hours
14. concentrationThe reaction mixture was concentrated
15. extractionthe residue was extracted with ethyl acetate
16. washthe organic layer was washed with a saturated brine
17. dry with materialdried over anhydrous magnesium sulfate
18. concentrationAfter concentrating the mixture under reduced pressure
19. customthe residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=80:20)
20. filtrationthe obtained solid was collected by filtration
21. washwashed with isopropyl ether
22. customdried

ORD record

ord-798c4beafcc24a77820e9272f71ac347

Source dataset

uspto-grants-2016_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09302996B2