Hydrochloric Acid → 1-(Oxan-4-yl)piperidin-4-amine dihydrochloride

HRID 624345Notes

Reaction equation

HRID 624345 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[CH2:12][CH2:11][CH:10]([NH:13]C(=O)OC(C)(C)C)[CH2:9][CH2:8]2)[CH2:3][CH2:2]1.[ClH:21]>ClCCl>[ClH:21].[ClH:21].[O:1]1[CH2:2][CH2:3][CH:4]([N:7]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9][CH2:8]2)[CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 45792109tert-butyl N-[1-(oxan-4-yl)piperidin-4-yl]carbamate

Product 1

HCID 451567511-(Oxan-4-yl)piperidin-4-amine dihydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of EXAMPLE 49A (52.57 g) in dichloromethane (900 mL) was treated with 4M aqueous HCl (462 mL), mixed vigorously at room temperature for 16 hours and concentrated.

Workup

  1. additionmixed vigorously at room temperature for 16 hours
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-aa29623e44e643e9b3bda13b771f984c
Source dataset
uspto-grants-2016_04
Patent number
US09303025B2

Reaction notes

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