1,3-Cyclohexanedione → 2-[(Dimethylamino)methylidene]cyclohexane-1,3-dione

HRID 62436

Reaction equation

HRID 62436 reaction equation
[C:1]1(=[O:8])[CH2:6][CH2:5][CH2:4][C:3](=[O:7])[CH2:2]1.[CH3:9][N:10]([CH:12](OC)OC)[CH3:11]>>[CH3:9][N:10]([CH:12]=[C:2]1[C:3](=[O:7])[CH2:4][CH2:5][CH2:6][C:1]1=[O:8])[CH3:11]

Participants

3

Reactant 2

HCID 104341,3-CyclohexanedioneHCID 78373Dimethylformamide dimethyl acetal

Product 1

HCID 3593532-[(Dimethylamino)methylidene]cyclohexane-1,3-dione

Conditions

Temperature
100 °C

Procedure

A mixture of cyclohexane-1,3-dione (33.6 g, 300 mmol) in DMF-DMA (120 ml) was heated to 100° C. and stirred for 1 h under nitrogen protection. The volatiles were concentrated under reduced pressure. The red solid (55 g crude) was used in the next step directly.

Workup

  1. concentrationThe volatiles were concentrated under reduced pressure

Sources & evidence

ORD record
ord-319371bbf428486bba88b1ed7d3dd6cb
Source dataset
uspto-grants-2016_09
Patent number
US09446130B2

Linked notes

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